Spider-Man

Spider-Man's superior strength, speed, and spider-sense overwhelm Daredevil's martial arts mastery.

Spider-Man's spider-sense and superior speed make Deadpool's healing factor irrelevant if he can't land a hit.

Spider-Man's superhuman stats and spider-sense give him a decisive edge over Batman's peak-human abilities.

Gear 5 Luffy's reality-warping rubber powers and Conqueror's Haki overwhelm Spider-Man's impressive but street-level abilities.

Iron Man's suit firepower and flight overcome Spider-Man's agility in a surprisingly competitive fight.

Homelander's superior strength, flight, and heat vision give him the edge over Spider-Man's agility and spider-sense.

Sanji's Ifrit Jambe and Germa enhancements give him the power edge despite Spider-Man's superior versatility and spider-sense.

Spider-Man is too fast to hit but too weak to hurt Hulk — Peter survives but can't win.

Spider-sense can't dodge lightning from a god — Thor's divine power outclasses Peter completely.

Universal-tier power vs street-level hero — this is not competitive at any level of analysis.

Thanos is a cosmic-tier titan — Spider-Man is brave but hopelessly outmatched.

Sonic's speed advantage is too extreme for spider-sense to compensate for.

Spider-Man's superior speed and spider-sense let him control the fight, though he can't permanently stop Wolverine.

Superman outclasses Spider-Man in every single physical metric by orders of magnitude.

Galactus is a cosmic entity who devours planets; Spider-Man is a street-level hero with no path to victory.

Ghost Rider's supernatural powers and invulnerability give him tools Spider-Man cannot counter.

Spider-Man's superior speed, strength, and spider-sense let him overwhelm Vader's Force powers.

Spider-Man's superhuman abilities and precognition overwhelm Cap's peak-human fighting skill.

Omni-Man is a planet-level threat whose power dwarfs Spider-Man's street-level abilities.

Wonder Woman's divine power, flight, and combat skill overwhelm Spider-Man's agility.

Speed Force makes this a non-contest — Flash is too fast for even spider-sense to matter.