HomelandervsSpider-Man

Homelander is physically stronger and more durable than Spider-Man, with the added advantages of flight and heat vision. Spider-Man's spider-sense would alert him to Homelander's attacks, and his agility is exceptional, but Homelander's laser vision is difficult to dodge indefinitely and can cut through most materials instantly.

Spider-Man's strength lets him lift roughly 10 tons; Homelander's strength feats suggest he operates in the hundreds-of-tons range at minimum. This gap means Peter's punches would annoy Homelander rather than hurt him, while Homelander's hits would be devastating.

Spider-Man's advantages are his intelligence, web-shooters, and superior agility. Peter could potentially blind Homelander with webbing and use hit-and-run tactics. But Homelander's heat vision gives him a ranged attack that webs cannot block, and his flight means Spider-Man cannot escape by swinging away. Homelander's durability also means Peter's standard attacks would have minimal effect.