Wade Wilson, the Merc with a Mouth, possesses a healing factor so absurd he's been decapitated, incinerated, and atomized—and trash-talked his way back from all of it. He's one of the most skilled combatants in the Marvel Universe, proficient with every weapon ever forged, and is the only character fully aware he's fictional. His real superpower is being so annoying that even Death herself fell in love with him.

Bitten by a radioactive spider and burdened with more responsibility than any teenager should carry, Peter Parker became the wisecracking wall-crawler known as Spider-Man. His spider-sense grants near-precognition in combat, and he can bench-press ten tons while dodging bullets with acrobatic flair. The smartest mouth in the Marvel Universe, backed by a genius-level intellect.