Deadpool

Spider-Man's spider-sense and superior speed make Deadpool's healing factor irrelevant if he can't land a hit.

Deadpool's immortal healing factor ultimately defeats Batman's tactical genius — you can't strategize against someone who won't stay down.

Deadpool literally can't die, but he also can't hurt Thanos — the Mad Titan wins through total physical dominance.

Hulk smashes Deadpool into paste repeatedly. Wade heals. Hulk smashes again. Repeat forever.

Ghost Rider's supernatural powers counter Deadpool's healing factor, and the Penance Stare bypasses physical durability.

Venom's superior strength and symbiote abilities give him the edge, despite Deadpool's healing factor.

Deadpool's healing factor and willingness to use lethal force give him the edge over Daredevil's superior martial arts.

Two healing-factor immortals — Wolverine's adamantium and superior combat skill give him the narrow edge.

Superman is in a different universe of power — Deadpool's healing factor just means he dies more creatively.

Cap is the better fighter, but Deadpool's healing factor makes it impossible to finish him.

Thor obliterates Deadpool repeatedly — Wade's healing factor keeps him alive but can't produce a win.

Doctor Doom's force fields, sorcery, and superior firepower overwhelm Deadpool despite the healing factor.

Iron Man's suit provides overwhelming firepower that keeps Deadpool permanently suppressed.

Goku atomizes Deadpool repeatedly, and Wade's healing factor just means he regenerates to get atomized again.

Homelander's superhuman stats let him damage Deadpool faster than the healing factor can recover, though he cannot truly kill Wade.