Goku atomizes Deadpool repeatedly, and Wade's healing factor just means he regenerates to get atomized again.
Deadpool's immortality keeps him alive against anything โ including universe-level attacks. But 'alive' and 'winning' are different things. Goku's ki attacks could vaporize Wade at the molecular level, and while the healing factor would eventually regenerate him, the cycle of destruction and regeneration is an infinite loop with no win condition for Deadpool.
Deadpool's conventional weapons (guns, swords) are completely useless against someone who can tank planet-busting attacks. Wade would probably make jokes while being repeatedly annihilated, which is on-brand.
Deadpool is immortal and his fourth-wall awareness could create unpredictable scenarios. He's technically killed the entire Marvel Universe once.
Goku's power exceeds anything in Deadpool's experience by infinite margins. Ki attacks can destroy Wade faster than he regenerates. Goku at full power is a force of nature that Wade has no tools against.
Goku wins every exchange overwhelmingly. Deadpool survives through immortality but has literally zero chance of hurting Goku. This is the pattern of every Deadpool-vs-cosmic matchup: can't die, can't win.
Deadpool also fights
Goku also fights