Wade Wilson, the Merc with a Mouth, possesses a healing factor so absurd he's been decapitated, incinerated, and atomized—and trash-talked his way back from all of it. He's one of the most skilled combatants in the Marvel Universe, proficient with every weapon ever forged, and is the only character fully aware he's fictional. His real superpower is being so annoying that even Death herself fell in love with him.

The Mad Titan of Marvel's cosmic hierarchy, Thanos is obsessed with universal balance and willing to snap half of existence out of reality to achieve it. Even without the Infinity Gauntlet, he can trade blows with the Hulk and outthink Reed Richards. With it, he is essentially God—capital G—with a chin that could cut diamonds.