Spider-ManvsWolverine

Spider-Man is faster, stronger, and has precognition. Wolverine has an indestructible skeleton, claws that cut through anything, and a healing factor that makes him virtually unkillable.

In their comic encounters, Spider-Man typically dominates the combat exchange — he's simply too fast and too agile for Wolverine to catch clean. Peter's webbing can temporarily immobilize Logan, and his 10-ton strength allows him to physically launch Wolverine away from him.

But Spider-Man can't finish the job. Wolverine heals from everything, eventually cuts through the webbing, and comes right back. It's a fight Peter wins on points but can't win by KO.

The key difference from the Deadpool matchup: Wolverine is a much better close-range combatant than Deadpool, so if he closes distance, the adamantium claws are a genuine threat even to Peter.