Bitten by a radioactive spider and burdened with more responsibility than any teenager should carry, Peter Parker became the wisecracking wall-crawler known as Spider-Man. His spider-sense grants near-precognition in combat, and he can bench-press ten tons while dodging bullets with acrobatic flair. The smartest mouth in the Marvel Universe, backed by a genius-level intellect.

The Mad Titan of Marvel's cosmic hierarchy, Thanos is obsessed with universal balance and willing to snap half of existence out of reality to achieve it. Even without the Infinity Gauntlet, he can trade blows with the Hulk and outthink Reed Richards. With it, he is essentially God—capital G—with a chin that could cut diamonds.