Thanos with the Infinity Gauntlet can rewrite reality itself — even Kratos's god-killing prowess has limits against omnipotence.
This depends entirely on which Thanos we're talking about. Base Thanos — the Mad Titan without any Infinity Stones — is a different conversation from Thanos with even a few stones, let alone the full Gauntlet. Let's address both scenarios.
Base Thanos is immensely powerful: he's gone toe-to-toe with Thor, Hulk, and Silver Surfer simultaneously. His durability lets him tank planet-busting attacks, and his energy projection can threaten cosmic beings. He's also a tactical genius with technology that spans galaxies. But Kratos has killed Zeus, overpowered Titans, and matched Thor's Mjolnir. In a straight physical fight, base Thanos and Kratos would be competitive, with Kratos's rage and divine weapons giving him a real chance.
But Thanos with the Infinity Gauntlet is a completely different entity. With all six stones, he snapped away half of all life in the universe with a thought. He can manipulate time, space, reality, power, the mind, and the soul — each at a cosmic level. He turned Wolverine's adamantium bones to rubber. He imprisoned cosmic abstracts. This is a level of power that transcends anything Kratos has faced.
Kratos's best argument is that he's overcome seemingly omnipotent foes before — Zeus with the power of Fear, and he's resisted reality-warping through sheer willpower. But the Infinity Gauntlet operates at a scale beyond the Greek and Norse pantheons combined. Thanos with the Gauntlet could simply erase Kratos from existence.
Kratos has killed gods who control fundamental forces: death, time, the ocean, lightning. His divine weapons — the Blades of Chaos and Leviathan Axe — are built to kill immortals. Against base Thanos, Kratos's rage, durability, and god-killing experience make this a genuine fight. His willpower has overcome reality-warping before, and he's defeated beings who claimed omnipotence within their domains.
Thanos with the Infinity Gauntlet controls all six fundamental forces of the Marvel universe simultaneously. He can rewrite reality, stop time, manipulate souls, and unleash infinite power — all with a thought. He defeated the cosmic abstracts of the Marvel universe, including Eternity itself. Even without the Gauntlet, base Thanos trades blows with planet-busters. With it, he's functionally omnipotent.
Thanos wins with the Infinity Gauntlet — that level of reality manipulation is beyond anything in God of War's cosmology. But against base Thanos, this becomes a genuinely competitive fight that Kratos could win. The Gauntlet is the difference-maker, and it's the version most people think of when they picture Thanos.
Kratos also fights
Thanos also fights