Don't let the pudgy appearance fool you—the hippopotamus is widely considered the most dangerous large animal in Africa, killing more humans annually than lions, leopards, and crocodiles combined. Its massive jaws open to a terrifying 180-degree angle and generate 1,800 PSI of bite force through foot-long canine teeth. At 4,000 pounds, it can outrun most humans on land and is absurdly agile in water.

The undisputed king of the African savanna, the lion commands respect with a bone-crushing bite force and claws that can shred steel-drum lids. Hunting in coordinated prides, a male lion's 550-pound frame and thunderous roar can be heard from five miles away. Few animals dare challenge this apex predator on its home turf.