The lion is faster, more agile, and has the predatory instincts to kill the Komodo before venom becomes a factor.
The African lion outclasses the Komodo dragon in virtually every physical category that matters in a direct confrontation. A male lion weighs 400-500 pounds compared to the Komodo's 150 pounds, and the lion is dramatically faster, more agile, and more powerful in close combat. Lions kill prey much larger than Komodo dragons regularly.
The Komodo dragon's primary weapon is its venomous bite, which delivers anticoagulants that cause shock and prolonged bleeding. This is effective against prey that the Komodo can bite and then track over hours or days. Against a lion, the Komodo would need to land a bite first, which is extremely difficult against a predator with superior reflexes and speed.
The lion would close distance quickly and use its powerful forelimbs and jaws to overpower the Komodo. A single bite to the neck or skull from the lion would be immediately fatal, while the Komodo's venom requires time to take effect โ time the lion would not give it.
The Komodo dragon's venomous bite delivers anticoagulants and bacteria that cause shock and blood loss. Its armored scales provide some protection, and it is a patient ambush predator with a powerful tail that can knock opponents off balance.
The lion is three times heavier, dramatically faster, and has powerful forelimbs with retractable claws designed for grappling and killing. Lions regularly take down prey much larger than Komodo dragons and kill with lethal efficiency.
The lion wins this convincingly through superior speed, size, and killing ability. The Komodo's venom is a slow weapon that requires time the lion would never allow. This is a clear mismatch in the lion's favor.
Komodo Dragon also fights
African Lion also fights