Goku's universal-level power and pure heart may let him overcome Ghost Rider's supernatural abilities.
This is a fascinating clash between overwhelming physical power and supernatural authority. Ghost Rider's hellfire burns the soul, and the Penance Stare forces targets to feel the pain they have caused. But Goku presents unique problems for both abilities.
The Penance Stare is the key question. Goku is fundamentally a good person who fights to protect others and improve himself. He has killed enemies, but always in defense of others or the universe. The Stare might be significantly weakened against someone with such a clean conscience. Additionally, Goku's ki defenses might provide some resistance to soul-based attacks.
Goku's raw power is universal โ his attacks can threaten dimensions. He could destroy Ghost Rider's physical form millions of times per second. While the Spirit of Vengeance reconstitutes, Goku's speed means Ghost Rider would never get a chance to attack. Whether Goku can permanently defeat a supernatural entity through sheer ki power is debatable, but he can certainly prevent Ghost Rider from ever acting.
Ghost Rider's hellfire burns the soul, bypassing Goku's physical durability. The Spirit of Vengeance cannot be permanently destroyed, and the Penance Stare targets sins regardless of physical power.
Goku's universal power can destroy Ghost Rider's form millions of times per second. His pure heart limits the Penance Stare, and his ki may provide spiritual defense. His speed prevents Ghost Rider from ever attacking.
Goku edges this through overwhelming speed that prevents Ghost Rider from acting, combined with a pure heart that weakens the Penance Stare. Ghost Rider's immortality prevents a true loss, but Goku controls the fight completely.
Ghost Rider also fights
Goku also fights